With the advent of the post-genomic era, the amount of genomic data has been increasing exponentially over the last decade. However, a great number of replication origin (oriCs) locations in archaeal genomes remain unknown. The web-based system Ori-Finder 2 are designed to predict the replication origins in archaeal genomes automatically, based on an integrated method comprising the analysis of base composition asymmetry used the Z-curve method, he distribution of ORB elements identified by FIMO tool, and the occurrence of genes frequently close to replication origin. Users can submit an annotated or unannotated genome sequence to the web server.(more)

• If you want to predict the replication origins in bacterial genome, please visit the Ori-Finder 1 web server [Gao and Zhang 2008].

Citation

• H. Luo, C.L. Quan, C. Peng, F. Gao (2018). Recent development of Ori-Finder system and DoriC database for microbial replication origins. Briefings in Bioinformatics, doi: 10.1093/bib/bbx174.
• H. Luo, C.T. Zhang and F. Gao (2014). Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes. Front. Microbiol. 5:482. doi: 10.3389/fmicb.2014.00482.[Abstract]

We welcome any feedback or corrections regarding the web server, and if you have any questions about Ori-Finder2, please don't hesitate to contact us ( Feng Gao; Hao Luo ). We will reply to you as soon as possible.